Any infection can lead to sepsis, and worldwide, one-third of people who develop sepsis die. Mortality from sepsis increases by as much as 8% for every hour that treatment is delayed. As many as 80% of sepsis deaths could be prevented with standardization and mobilization of tools and protocols already available in many institutions. Sepsis was rated the most expensive condition to treat in hospitals, with an estimated $55 million spent on sepsis in the US each day, and $62 billion spent annually worldwide. Many healthcare organizations have shown it is possible to successfully implement and sustain improvements that reduce sepsis morbidity and mortality. This blueprint outlines the actionable steps organizations can take to successfully reduce/improve sepsis rates and summarizes the available evidence-based practice protocols.