A 2016 study showed one out of every two surgeries has a medication error or an adverse drug event, a major contributing factor to medication errors being the leading preventable cause of death for patients in the US. In addition to the high rate of surgery-related medication errors, drug infusion pump errors are another significant source of patient harm. Beyond the human toll, medication errors cost of about $42 billion a year globally. To reduce medication errors, hospitals and healthcare systems can implement a host of new approaches and technologies, such as automated infusion and IV injectable technologies, electronic medical records, and checklists. This blueprint outlines a number of protocols to help improve quality of care and to foster a culture of safety around medication practices and procedures.